Gene Variant Detail

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Gene HRAS
Variant G12D
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS G12D does not lie within any known functional domains of the Hras protein (UniProt.org). G12D results in decreased Hras GTPase activity, loss of sensitivity to GTPase-activating proteins, thus leads to transformation of cells in culture (PMID: 24224811, PMID: 6092966).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12D

HRAS mutant HRAS G12X HRAS G12D

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Transcript NM_005343.4
gDNA chr11:g.534288C>T
cDNA c.35G>A
Protein p.G12D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_005343 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_176795 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534288C>T c.35G>A p.G12D RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05638698 Phase II Balstilimab + QS21 + TG01 QS21 + TG01 Tg01 Vaccine / Qs-21 Stimulon™ With Or Without Balstilimab As Maintenance Therapy Following Adjuvant Chemotherapy In Patients With Resected Pancreatic Cancer (TESLA) Active, not recruiting USA 0
NCT03745326 Phase Ib/II Aldesleukin + anti-KRAS G12D mTCR cells + Cyclophosphamide + Fludarabine Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients Recruiting USA 0