Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene HRAS
Variant G12R
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS G12R does not lie within any known functional domains of the Hras protein (UniProt.org). G12R results in decreased Hras GTPase activity and leads to transformation of cells in culture (PMID: 3042780, PMID: 6092966).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12R

HRAS mutant HRAS G12X HRAS G12R

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_005343.4
gDNA chr11:g.534289C>G
cDNA c.34G>C
Protein p.G12R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442.2 chr11:g.534289C>G c.34G>C p.G12R RefSeq GRCh38/hg38
NM_176795 chr11:g.534289C>G c.34G>C p.G12R RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534289C>G c.34G>C p.G12R RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534289C>G c.34G>C p.G12R RefSeq GRCh38/hg38
NM_005343 chr11:g.534289C>G c.34G>C p.G12R RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534289C>G c.34G>C p.G12R RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534289C>G c.34G>C p.G12R RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534289C>G c.34G>C p.G12R RefSeq GRCh38/hg38
NM_001130442 chr11:g.534289C>G c.34G>C p.G12R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05638698 Phase II Balstilimab + QS21 + TG01 QS21 + TG01 Tg01 Vaccine / Qs-21 Stimulon™ With Or Without Balstilimab As Maintenance Therapy Following Adjuvant Chemotherapy In Patients With Resected Pancreatic Cancer (TESLA) Active, not recruiting USA 0