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HRAS V29Cfs*19 - Gene Variant Detail

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Gene HRAS
Variant V29Cfs*19
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions HRAS V29Cfs*19 indicates a shift in the reading frame starting at amino acid 29 and terminating 19 residues downstream causing a premature truncation of the 189 amino acid Hras protein (UniProt.org). Due to the loss of the GTP binding domain (UniProt.org), V29Cfs*19 is predicted to lead to a loss of Hras protein function resulting in inactivation of downstream signaling.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS inact mut HRAS V29Cfs*19

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Transcript NM_005343.4
gDNA chr11:g.534242dupA
cDNA c.84dupT
Protein p.V29Cfs*19
Source Database RefSeq
Genome Build GRCh38/hg38

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