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HRAS G13C - Gene Variant Detail

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Gene HRAS
Variant G13C
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS G13C is hotspot mutation that lies within the GTP binding domain of the Hras protein (UniProt.org). G13C results in decreased Hras GTPase activity and loss of response to GTPase-activating proteins, leading to activation of downstream signaling and cell senescence in culture (PMID: 24224811, PMID: 21850009).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G13C

HRAS mutant HRAS G13X HRAS G13C

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Transcript NM_005343.4
gDNA chr11:g.534286C>A
cDNA c.37G>T
Protein p.G13C
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.