HRAS G13I
Gene Variant Detail

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Gene HRAS
Variant G13I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions HRAS G13I is hotspot mutation that lies within the GTP-binding region of the Hras protein (UniProt.org). G13I has been identified in the scientific literature (PMID: 26974156, PMID: 22817889), but has not been biochemically characterized and therefore, its effect on Hras protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS G13X HRAS G13I

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Transcript NM_005343.4
gDNA chr11:g.534285_534286delGGinsAT
cDNA c.37_38delGGinsAT
Protein p.G13I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795 chr11:g.534285_534286delCCinsAT c.37_38delGGinsAT p.G13I RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534285_534286delGGinsAT c.37_38delGGinsAT p.G13I RefSeq GRCh38/hg38
NM_005343 chr11:g.534285_534286delCCinsAT c.37_38delGGinsAT p.G13I RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534285_534286delGGinsAT c.37_38delGGinsAT p.G13I RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534285_534286delGGinsAT c.37_38delGGinsAT p.G13I RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534285_534286delGGinsAT c.37_38delGGinsAT p.G13I RefSeq GRCh38/hg38
NM_001130442 chr11:g.534285_534286delCCinsAT c.37_38delGGinsAT p.G13I RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534285_534286delGGinsAT c.37_38delGGinsAT p.G13I RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534285_534286delGGinsAT c.37_38delGGinsAT p.G13I RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References