Gene Variant Detail

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Gene HRAS
Variant G13V
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS G13V is a hotspot mutation that lies within the GTP binding domain of the Hras protein (UniProt.org). G13V does not affect Hras GTPase activity, but results in a loss of response to GTPase-activating proteins, leading to increased GTP-bound Hras in culture (PMID: 24224811).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G13V

HRAS mutant HRAS G13X HRAS G13V

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Transcript NM_005343.4
gDNA chr11:g.534285C>A
cDNA c.38G>T
Protein p.G13V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442.3 chr11:g.534285C>A c.38G>T p.G13V RefSeq GRCh38/hg38
NM_176795 chr11:g.534285C>A c.38G>T p.G13V RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534285C>A c.38G>T p.G13V RefSeq GRCh38/hg38
NM_001130442 chr11:g.534285C>A c.38G>T p.G13V RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534285C>A c.38G>T p.G13V RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534285C>A c.38G>T p.G13V RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534285C>A c.38G>T p.G13V RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534285C>A c.38G>T p.G13V RefSeq GRCh38/hg38
NM_005343 chr11:g.534285C>A c.38G>T p.G13V RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References