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HRAS G13V - Gene Variant Detail

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Gene HRAS
Variant G13V
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS G13V is a hotspot mutation that lies within the GTP binding domain of the Hras protein (UniProt.org). G13V does not affect Hras GTPase activity, but results in a loss of response to GTPase-activating proteins, leading to increased GTP-bound Hras in culture (PMID: 24224811).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G13V

HRAS mutant HRAS G13X HRAS G13V

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Transcript NM_005343.4
gDNA chr11:g.534285C>A
cDNA c.38G>T
Protein p.G13V
Source Database RefSeq
Genome Build GRCh38/hg38

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