HRAS Q61H
Gene Variant Detail

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Gene HRAS
Variant Q61H
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions HRAS Q61H does not lie within any known functional domains of the Hras protein (UniProt.org). Q61H is transforming in culture (PMID: 3510078), and can be predicted to lead to a loss of protein function and activation of downstream signaling based on the effect of KRAS Q61H (PMID: 20147967).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS Q61H

HRAS mutant HRAS Q61X HRAS Q61H

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Transcript NM_005343.4
gDNA chr11:g.533873C>A
cDNA c.183G>T
Protein p.Q61H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442.2 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_001130442 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_176795 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_005343 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS Q61H uterine cancer sensitive BTX-6654 Preclinical - Cell culture Actionable In a preclinical study, BTX-6654 inhibited proliferation of a uterine cancer cell line harboring HRAS Q61H in 3D culture (PMID: 38224565). 38224565
HRAS Q61H uterine cancer sensitive BTX-7312 Preclinical - Cell culture Actionable In a preclinical study, BTX-7312 inhibited proliferation of a uterine cancer cell line harboring HRAS Q61H in 3D culture (PMID: 38224565). 38224565