Gene Variant Detail

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Gene HRAS
Variant Q61H
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS Q61H does not lie within any known functional domains of the Hras protein (UniProt.org). Q61H results in decreased Hras GTPase activity and leads to transformation of cells in culture (PMID: 3510078).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS Q61H

HRAS mutant HRAS Q61X HRAS Q61H

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Transcript NM_005343.4
gDNA chr11:g.533873C>A
cDNA c.183G>T
Protein p.Q61H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.4 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_176795 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_005343 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_001130442 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533873C>A c.183G>T p.Q61H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS Q61H uterine cancer sensitive BTX-6654 Preclinical - Cell culture Actionable In a preclinical study, BTX-6654 inhibited proliferation of a uterine cancer cell line harboring HRAS Q61H in 3D culture (PMID: 38224565). 38224565
HRAS Q61H uterine cancer sensitive BTX-7312 Preclinical - Cell culture Actionable In a preclinical study, BTX-7312 inhibited proliferation of a uterine cancer cell line harboring HRAS Q61H in 3D culture (PMID: 38224565). 38224565