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Gene | HRAS |
Variant | Q61H |
Impact List | missense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | HRAS Q61H does not lie within any known functional domains of the Hras protein (UniProt.org). Q61H is transforming in culture (PMID: 3510078), and can be predicted to lead to a loss of protein function and activation of downstream signaling based on the effect of KRAS Q61H (PMID: 20147967). |
Associated Drug Resistance | |
Category Variants Paths |
HRAS mutant HRAS act mut HRAS Q61H HRAS mutant HRAS Q61X HRAS Q61H |
Transcript | NM_005343.4 |
gDNA | chr11:g.533873C>A |
cDNA | c.183G>T |
Protein | p.Q61H |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |