Gene Variant Detail

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Gene HRAS
Variant Q61L
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS Q61L does not lie within any known functional domains of the Hras protein (UniProt.org). Q61L results in decreased Hras GTPase activity and leads to transformation of cells in culture (PMID: 23487764, PMID: 3510078).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS Q61L

HRAS mutant HRAS Q61X HRAS Q61L

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Transcript NM_005343.4
gDNA chr11:g.533874T>A
cDNA c.182A>T
Protein p.Q61L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343 chr11:g.533874T>A c.182A>T p.Q61L RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533874T>A c.182A>T p.Q61L RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533874T>A c.182A>T p.Q61L RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533874T>A c.182A>T p.Q61L RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533874T>A c.182A>T p.Q61L RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533874T>A c.182A>T p.Q61L RefSeq GRCh38/hg38
NM_001130442 chr11:g.533874T>A c.182A>T p.Q61L RefSeq GRCh38/hg38
NM_176795 chr11:g.533874T>A c.182A>T p.Q61L RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533874T>A c.182A>T p.Q61L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
HRAS Q61L loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF D594E HRAS Q61L
ALK F1174L HRAS Q61L