Gene Variant Detail

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Gene HRAS
Variant R123C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions HRAS R123C does not lie within any known functional domains of the Hras protein (UniProt.org). R123C fails to interact with oncogenic Kras, reduce Erk phosphorylation, and decrease cell proliferation in Kras-mutant cells in culture (PMID: 36635501), but has not been fully biochemically characterized and therefore, its effect on Hras protein function is unknown.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS R123C

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Transcript NM_005343.4
gDNA chr11:g.533536G>A
cDNA c.367C>T
Protein p.R123C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.5 chr11:g.533536G>A c.367C>T p.R123C RefSeq GRCh38/hg38
NM_176795 chr11:g.533536G>A c.367C>T p.R123C RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533536G>A c.367C>T p.R123C RefSeq GRCh38/hg38
NM_005343 chr11:g.533536G>A c.367C>T p.R123C RefSeq GRCh38/hg38
NM_001130442 chr11:g.533536G>A c.367C>T p.R123C RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533536G>A c.367C>T p.R123C RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533536G>A c.367C>T p.R123C RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533536G>A c.367C>T p.R123C RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533536G>A c.367C>T p.R123C RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References