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Gene | HRAS |
Variant | R123C |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | HRAS R123C does not lie within any known functional domains of the Hras protein (UniProt.org). R123C fails to interact with oncogenic Kras, reduce Erk phosphorylation, and decrease cell proliferation in Kras-mutant cells in culture (PMID: 36635501), but has not been fully biochemically characterized and therefore, its effect on Hras protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
HRAS mutant HRAS R123C |
Transcript | NM_005343.4 |
gDNA | chr11:g.533536G>A |
cDNA | c.367C>T |
Protein | p.R123C |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_005343 | chr11:g.533536G>A | c.367C>T | p.R123C | RefSeq | GRCh38/hg38 |
NM_176795.4 | chr11:g.533536G>A | c.367C>T | p.R123C | RefSeq | GRCh38/hg38 |
NM_005343.3 | chr11:g.533536G>A | c.367C>T | p.R123C | RefSeq | GRCh38/hg38 |
NM_001130442 | chr11:g.533536G>A | c.367C>T | p.R123C | RefSeq | GRCh38/hg38 |
NM_176795 | chr11:g.533536G>A | c.367C>T | p.R123C | RefSeq | GRCh38/hg38 |
NM_001130442.3 | chr11:g.533536G>A | c.367C>T | p.R123C | RefSeq | GRCh38/hg38 |
NM_001130442.2 | chr11:g.533536G>A | c.367C>T | p.R123C | RefSeq | GRCh38/hg38 |
NM_005343.4 | chr11:g.533536G>A | c.367C>T | p.R123C | RefSeq | GRCh38/hg38 |
NM_176795.5 | chr11:g.533536G>A | c.367C>T | p.R123C | RefSeq | GRCh38/hg38 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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