Gene Variant Detail

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Gene FGFR2
Variant A264T
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 A264T lies within Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). A264T results in proliferation similar to wild-type Fgfr2 in a competition assay but increased transformation activity in cultured cells (PMID: 34272467), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 A264T

FGFR2 mutant FGFR2 exon7 FGFR2 A264T

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Transcript NM_000141.5
gDNA chr10:g.121520128C>T
cDNA c.790G>A
Protein p.A264T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144918 chr10:g.121515269C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144917 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144919 chr10:g.121518712C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144919.2 chr10:g.121518712C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144916.1 chr10:g.121515269C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144916 chr10:g.121515269C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144918.1 chr10:g.121515269C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144916.2 chr10:g.121515269C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_022970 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144913 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144919.1 chr10:g.121518712C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_000141 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001320658 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520128C>T c.790G>A p.A264T RefSeq GRCh38/hg38
NM_001144918.2 chr10:g.121515269C>T c.790G>A p.A264T RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
FGFR2 A264T gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor