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Gene FGFR2
Variant A389T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 A389T lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). A389T results in proliferation similar to wild-type Fgfr2 in a competition assay (PMID: 34272467) and is not transforming in culture in one study (PMID: 18552176), but increased transformation activity in cultured cells in another study (PMID: 34272467), and therefore, its effect on Fgfr2 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 A389T

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Transcript NM_000141.5
gDNA chr10:g.121515239C>T
cDNA c.1165G>A
Protein p.A389T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658 chr10:g.121515239C>T c.1165G>A p.A389T RefSeq GRCh38/hg38
XM_017015923 chr10:g.121503848C>T c.1165G>A p.A389T RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515239C>T c.1165G>A p.A389T RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515239C>T c.1165G>A p.A389T RefSeq GRCh38/hg38
XM_024447889.1 chr10:g.121503848C>T c.1165G>A p.A389T RefSeq GRCh38/hg38
NM_000141 chr10:g.121515239C>T c.1165G>A p.A389T RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121515239C>T c.1165G>A p.A389T RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121515239C>T c.1165G>A p.A389T RefSeq GRCh38/hg38
XM_024447889.2 chr10:g.121503848C>T c.1165G>A p.A389T RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 A389T Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 A389T were sensitive to treatment with AZD4547 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 A389T Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 A389T were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 A389T Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 A389T were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 A389T Advanced Solid Tumor predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 A389T were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 A389T Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 A389T were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 A389T Advanced Solid Tumor predicted - sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 A389T were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467