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Gene FGFR2
Variant D304N
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 D304N lies within Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). D304N has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon7 FGFR2 D304N

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Transcript NM_000141.5
gDNA chr10:g.121520008C>T
cDNA c.910G>A
Protein p.D304N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024447887.2 chr10:g.121515284C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_001144917 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_001320658 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
XM_024447889.2 chr10:g.121515284C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_001144913 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_022970 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
XM_024447887.1 chr10:g.121515284C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
XM_024447889.1 chr10:g.121515284C>T c.910G>A p.D304N RefSeq GRCh38/hg38
XM_017015923 chr10:g.121515284C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_000141 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520008C>T c.910G>A p.D304N RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References