NRAS G115Efs*46
Gene Variant Detail

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Gene NRAS
Variant G115Efs*46
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS G115Efs*46 indicates a shift in the reading frame starting at amino acid 115 and terminating 46 residues downstream causing a premature truncation of the 189 amino acid Nras protein (UniProt.org). Due to the loss of the CAAX motif (PMID: 6087162, PMID: 21924373), G115Efs*46 is predicted to lead to a loss of Nras protein function resulting in inactivation of downstream signaling.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon4 NRAS G115Efs*46

NRAS mutant NRAS inact mut NRAS G115Efs*46

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Transcript NM_002524.5
gDNA chr1:g.114709677delC
cDNA c.344delG
Protein p.G115Efs*46
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114709677delC c.344delG p.G115Efs*46 RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114709677delC c.344delG p.G115Efs*46 RefSeq GRCh38/hg38
NM_002524 chr1:g.114709677delC c.344delG p.G115Efs*46 RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS G115Efs*46 colorectal cancer predicted - resistant Cetuximab Clinical Study - Cohort Actionable In a retrospective analysis, NRAS G115Efs*46 was identified at a frequency of >1% in 3 of 23 patients with metastatic colorectal cancer who did not respond to anti-EGFR therapy (Erbitux (cetuximab), n=12 or Vectibix (panitumumab), n=11), and was associated with a lack of response (p=0.029) to EGFR-targeted therapy (PMID: 32796636). 32796636
NRAS G115Efs*46 colorectal cancer predicted - resistant Panitumumab Clinical Study - Cohort Actionable In a retrospective analysis, NRAS G115Efs*46 was identified at a frequency of >1% in 3 of 23 patients with metastatic colorectal cancer who did not respond to anti-EGFR therapy (Erbitux (cetuximab), n=12 or Vectibix (panitumumab), n=11), and was associated with a lack of response (p=0.029) to EGFR-targeted therapy (PMID: 32796636). 32796636