FGFR2 T764fs - Gene Variant Detail

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Gene FGFR2
Variant T764fs
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions FGFR2 T764fs results in a change in the amino acid sequence of the Fgfr2 protein beginning at aa 764 of 821, likely resulting in premature truncation of the functional protein (UniProt.org). T764fs has been identified in sequencing studies (PMID: 35280424), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Jan 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 T764fs

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Transcript NM_000141.5
gDNA chr10:g.(121483709_121483710)
cDNA c.(2290_2289)
Protein p.T764fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.(121483709_121483710) c.(2290_2289) p.T764fs RefSeq GRCh38/hg38
NM_000141.4 chr10:g.(121483709_121483710) c.(2290_2289) p.T764fs RefSeq GRCh38/hg38
NM_000141 chr10:g.(121483709_121483710) c.(2290_2289) p.T764fs RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References