Gene Variant Detail

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Gene PTEN
Variant T202I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PTEN T202I lies within the C2 tensin-type domain of the Pten protein (UniProt.org). T202I leads to reduced developmental growth rate in flies (PMID: 32350270) and reduced Pten protein expression and increased sumoylation, however, retains the ability to suppress PI3K signaling, and demonstrates nuclear localization and lipid phosphatase activity similar to wild-type Pten in culture (PMID: 32150788, PMID: 21828076), and therefore, its effect on Pten protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN T202I

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Transcript NM_000314.8
gDNA chr10:g.87952230C>T
cDNA c.605C>T
Protein p.T202I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314 chr10:g.87952230C>T c.605C>T p.T202I RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87952230C>T c.605C>T p.T202I RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87952230C>T c.605C>T p.T202I RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References