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Gene PTEN
Variant N356H
Impact List missense
Protein Effect no effect
Gene Variant Descriptions PTEN N356H does not lie within any known functional domains of the Pten protein (UniProt.org). N356H demonstrates Pten protein stability and suppression of Akt phosphorylation similar to wild-type Pten in cell culture (PMID: 32350270).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN N356H

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Transcript NM_000314.8
gDNA chr10:g.87965326A>C
cDNA c.1066A>C
Protein p.N356H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87965326A>C c.1066A>C p.N356H RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87965326A>C c.1066A>C p.N356H RefSeq GRCh38/hg38
NM_000314 chr10:g.87965326A>C c.1066A>C p.N356H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References