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Gene PTEN
Variant I135T
Impact List missense
Protein Effect no effect
Gene Variant Descriptions PTEN I135T lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). I135T results in minimal colony formation in yeast (PMID: 32471850), and leads to Pten protein stability and suppression of Akt phosphorylation similar to wild-type Pten in cell culture, and normal developmental growth in flies (PMID: 32350270).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN I135T

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Transcript NM_000314.8
gDNA chr10:g.87933163T>C
cDNA c.404T>C
Protein p.I135T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.8 chr10:g.87933163T>C c.404T>C p.I135T RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87933163T>C c.404T>C p.I135T RefSeq GRCh38/hg38
NM_000314 chr10:g.87933163T>C c.404T>C p.I135T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References