Gene Variant Detail

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Gene PTEN
Variant I203V
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions PTEN I203V lies within the C2 tensin-type domain of the Pten protein (UniProt.org). I203V demonstrates decreased Pten protein stability, but results in suppression of Akt phosphorylation similar to wild-type Pten in culture, and leads to normal developmental growth in flies (PMID: 32350270), and therefore, is predicted to have no effect on Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN I203V

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Transcript NM_000314.8
gDNA chr10:g.87952232A>G
cDNA c.607A>G
Protein p.I203V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001304718 chr10:g.87965458A>G c.607A>G p.I203V RefSeq GRCh38/hg38
NM_000314 chr10:g.87952232A>G c.607A>G p.I203V RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87952232A>G c.607A>G p.I203V RefSeq GRCh38/hg38
NM_001304718.1 chr10:g.87965458A>G c.607A>G p.I203V RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87952232A>G c.607A>G p.I203V RefSeq GRCh38/hg38
NM_001304718.2 chr10:g.87965458A>G c.607A>G p.I203V RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References