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Gene TP53
Variant Q331*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 Q331* results in a premature truncation of the Tp53 protein at amino acid 331 of 393 (UniProt.org). Q331* has not been biochemically characterized however, due to the effects of truncation mutations downstream of Q331 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon9 TP53 Q331*

TP53 mutant TP53 inact mut TP53 Q331*

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Transcript NM_000546.6
gDNA chr17:g.7673537G>A
cDNA c.991C>T
Protein p.Q331*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407268.1 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001126113 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001126114 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_000546 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_001126112 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673537G>A c.991C>T p.Q331* RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 Q331* lung non-small cell carcinoma sensitive AZ32 + Radiotherapy Preclinical - Cell line xenograft Actionable In a preclinical study, AZ32 treatment increased sensitivity to radiotherapy and demonstrated increased tumor growth inhibition and prolonged survival compared to radiation alone in an intracranial cell line xenograft model of non-small cell lung cancer brain metastasis harboring TP53 Q331* (PMID: 29769307). 29769307