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Gene PTEN
Variant T363N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PTEN T363N does not lie within any known functional domains of the Pten protein (UniProt.org). T363N demonstrates Pten protein stability and suppression of Akt phosphorylation similar to wild-type Pten in cell culture, however, leads to impaired developmental growth in flies (PMID: 32350270), and therefore, its effect on Pten protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN T363N

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Transcript NM_000314.8
gDNA chr10:g.87965348C>A
cDNA c.1088C>A
Protein p.T363N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314 chr10:g.87965348C>A c.1088C>A p.T363N RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87965348C>A c.1088C>A p.T363N RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87965348C>A c.1088C>A p.T363N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References