PIK3CA E453Q
Gene Variant Detail

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Gene PIK3CA
Variant E453Q
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA E453Q lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). E453Q confers a gain of function to Pik3ca as indicated by increased lipid kinase activity in cell culture (PMID: 15930273) and demonstrates increased transformation ability in two different cell lines, as compared to wild-type Pik3ca (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA E453Q

PIK3CA mutant PIK3CA exon8 PIK3CA E453Q

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Transcript NM_006218.4
gDNA chr3:g.179210291G>C
cDNA c.1357G>C
Protein p.E453Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218 chr3:g.179210291G>C c.1357G>C p.E453Q RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210291G>C c.1357G>C p.E453Q RefSeq GRCh38/hg38
XM_011512894 chr3:g.179210291G>C c.1357G>C p.E453Q RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210291G>C c.1357G>C p.E453Q RefSeq GRCh38/hg38
XM_006713658 chr3:g.179210291G>C c.1357G>C p.E453Q RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210291G>C c.1357G>C p.E453Q RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210291G>C c.1357G>C p.E453Q RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210291G>C c.1357G>C p.E453Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References