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Gene FGFR3
Variant N428S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR3 N428S lies within the cytoplasmic domain of the Fgfr3 protein (UniProt.org). N428S has been identified in sequencing studies (PMID: 32699558), but has not been biochemically characterized and therefore, its effect on Fgfr3 protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 N428S

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Transcript NM_000142.5
gDNA chr4:g.1804840A>G
cDNA c.1283A>G
Protein p.N428S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022965.4 chr4:g.1805643A>G c.1283A>G p.N428S RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1804840A>G c.1283A>G p.N428S RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1804840A>G c.1283A>G p.N428S RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1804840A>G c.1283A>G p.N428S RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1804840A>G c.1283A>G p.N428S RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1804840A>G c.1283A>G p.N428S RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1804840A>G c.1283A>G p.N428S RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References