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Gene FLT3
Variant M665T
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 M665T lies within the protein kinase domain of the Flt3 protein (UniProt.org). M665T results in similar JAK/STAT signaling, but increased NF-kappaB signaling compared to wild-type Flt3 in a reporter assay (PMID: 29464843), and therefore, is predicted to lead to a gain of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 M665T

FLT3 mutant FLT3 exon16 FLT3 M665T

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Transcript NM_004119.3
gDNA chr13:g.28028237A>G
cDNA c.1994T>C
Protein p.M665T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28028237A>G c.1994T>C p.M665T RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28028237A>G c.1994T>C p.M665T RefSeq GRCh38/hg38
XM_017020486.2 chr13:g.28024941A>G c.1994T>C p.M665T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References