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Gene TP53
Variant F134fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 F134fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 134 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). F134fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of F134 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 F134fs

TP53 mutant TP53 inact mut TP53 F134fs

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Transcript NM_000546.6
gDNA chr17:g.(7675212_7675213)
cDNA c.(400_399)
Protein p.F134fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114.2 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7675212_7675213) c.(400_399) p.F134fs RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References