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Gene TP53
Variant G279fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 G279fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 279 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). G279fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of G279 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 G279fs

TP53 mutant TP53 inact mut TP53 G279fs

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Transcript NM_000546.6
gDNA chr17:g.(7673785_7673786)
cDNA c.(835_834)
Protein p.G279fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.2 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7673785_7673786) c.(835_834) p.G279fs RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Protein Effect Treatment Approaches
TP53 G279fs loss of function - predicted