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Gene TP53
Variant S149fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 S149fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 149 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). S149fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of S149 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 S149fs

TP53 mutant TP53 inact mut TP53 S149fs

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Transcript NM_000546.6
gDNA chr17:g.(7675167_7675168)
cDNA c.(445_444)
Protein p.S149fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407266.1 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7675167_7675168) c.(445_444) p.S149fs RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
TP53 S149fs loss of function - predicted