Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | TP53 |
Variant | K132R |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 K132R lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). K132R is associated with tumor formation in mouse models (PMID: 32784519), but has not been biochemically characterized and therefore, it effect on Tp53 protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon5 TP53 K132R |
Transcript | NM_000546.6 |
gDNA | chr17:g.7675217T>C |
cDNA | c.395A>G |
Protein | p.K132R |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_000546.5 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001276698.3 | chr17:g.7673748T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001126112.2 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001126114.2 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001126113.2 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7675217T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001276697.3 | chr17:g.7673748T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
NM_001276699.3 | chr17:g.7673748T>C | c.395A>G | p.K132R | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|