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Gene PIK3CA
Variant E545A
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA E545A is a hotspot mutation that lies within the PIK helical domain of the Pik3ca protein (UniProt.org). E545A confers a gain of function on the Pik3ca protein as demonstrated by increased phosphorylation of Akt and transformation in cell culture (PMID: 17376864, PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA E545A

PIK3CA mutant PIK3CA exon10 PIK3CA E545X PIK3CA E545A

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Transcript NM_006218.4
gDNA chr3:g.179218304A>C
cDNA c.1634A>C
Protein p.E545A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218 chr3:g.179218304A>C c.1634A>C p.E545A RefSeq GRCh38/hg38
XM_011512894 chr3:g.179218304A>C c.1634A>C p.E545A RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218304A>C c.1634A>C p.E545A RefSeq GRCh38/hg38
XM_006713658 chr3:g.179218304A>C c.1634A>C p.E545A RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179218304A>C c.1634A>C p.E545A RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179218304A>C c.1634A>C p.E545A RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179218304A>C c.1634A>C p.E545A RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179218304A>C c.1634A>C p.E545A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
PIK3CA E545A gain of function Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor
FGFR3 S249C PIK3CA E545A
PIK3CA E453K PIK3CA E545A