HRAS R135K
Gene Variant Detail

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Gene HRAS
Variant R135K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions HRAS R135K does not lie within any known functional domains of the Hras protein (UniProt.org). R135K is predicted to disrupt the allosteric interaction within Hras by molecular dynamics simulation (PMID: 29072601), and results in decreased NS1 binding in the context of HRAS G12C, resulting in resistance to NS1, in cultured cells (PMID: 27820802) and leads to loss of binding to NS1 in cultured cells in another study (PMID: 36252024), but has not been fully biochemically characterized and therefore, its effect on Hras protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

HRAS mutant HRAS R135K

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Transcript NM_005343.4
gDNA chr11:g.533499_533500delCGinsAA
cDNA c.403_404delCGinsAA
Protein p.R135K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533499_533500delCGinsAA c.403_404delCGinsAA p.R135K RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533499_533500delCGinsAA c.403_404delCGinsAA p.R135K RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533499_533500delCGinsAA c.403_404delCGinsAA p.R135K RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533499_533500delCGinsAA c.403_404delCGinsAA p.R135K RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533499_533500delCGinsAA c.403_404delCGinsAA p.R135K RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533499_533500delCGinsAA c.403_404delCGinsAA p.R135K RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References