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Gene PIK3CA
Variant E545V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA E545V is a hotspot mutation that lies within the PIK helical domain of the Pik3ca protein (UniProt.org). E545V has been identified in sequencing studies (PMID: 29482551, PMID: 24504419), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Nov 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon10 PIK3CA E545X PIK3CA E545V

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Transcript NM_006218.4
gDNA chr3:g.179218304A>T
cDNA c.1634A>T
Protein p.E545V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179218304A>T c.1634A>T p.E545V RefSeq GRCh38/hg38
NM_006218 chr3:g.179218304A>T c.1634A>T p.E545V RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179218304A>T c.1634A>T p.E545V RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179218304A>T c.1634A>T p.E545V RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218304A>T c.1634A>T p.E545V RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179218304A>T c.1634A>T p.E545V RefSeq GRCh38/hg38
XM_006713658 chr3:g.179218304A>T c.1634A>T p.E545V RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179218304A>T c.1634A>T p.E545V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
PIK3CA E545V unknown Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor