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Gene ARID1A
Variant A1682fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ARID1A A1682fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1682 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). A1682fs has not been characterized, however, due to the effects of other truncation mutations downstream of A1682 (PMID: 29736026), is predicted to lead to a loss of Arid1a protein function.
Associated Drug Resistance
Category Variants Paths

ARID1A mutant ARID1A inact mut ARID1A A1682fs

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Transcript NM_006015.6
gDNA chr1:g.(26775626_26775627)
cDNA c.(5044_5043)
Protein p.A1682fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006015.6 chr1:g.(26775626_26775627) c.(5044_5043) p.A1682fs RefSeq GRCh38/hg38
NM_006015.5 chr1:g.(26775626_26775627) c.(5044_5043) p.A1682fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Protein Effect Treatment Approaches
ARID1A A1682fs loss of function - predicted EZH2 inhibitor