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Gene PIK3CA
Variant E547K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA E547K is a hotspot mutation that lies within the PIK helical domain of the Pik3ca protein (PMID: 27177864). E547K results in decreased cell viability compared to wild-type Pik3ca in one of two cell lines in culture (PMID: 29533785), but has not been biochemically characterized, and therefore, its effect on Pik3ca protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon10 PIK3CA E547K

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Transcript NM_006218.4
gDNA chr3:g.179218309G>A
cDNA c.1639G>A
Protein p.E547K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.3 chr3:g.179218309G>A c.1639G>A p.E547K RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179218309G>A c.1639G>A p.E547K RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179218309G>A c.1639G>A p.E547K RefSeq GRCh38/hg38
NM_006218 chr3:g.179218309G>A c.1639G>A p.E547K RefSeq GRCh38/hg38
XM_006713658 chr3:g.179218309G>A c.1639G>A p.E547K RefSeq GRCh38/hg38
XM_011512894 chr3:g.179218309G>A c.1639G>A p.E547K RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179218309G>A c.1639G>A p.E547K RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179218309G>A c.1639G>A p.E547K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
PIK3CA E547K unknown