PIK3CA E81K
Gene Variant Detail

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Gene PIK3CA
Variant E81K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA E81K lies within the PI3K-ABD domain of the Pik3ca protein (UniProt.org). The functional effect of E81K is conflicting, as it results in cell proliferation, migration, and Akt phosphorylation similar to wild-type Pik3ca in culture and is not transforming in one study (PMID: 34779417), but in other studies it leads to decreased cell proliferation and cell viability (PMID: 29533785) and increased Akt phosphorylation, activation of Mtor signaling, and growth advantage in patient-derived dermal fibroblasts in culture (PMID: 25915946), and therefore, its effect on Pik3ca protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA E81K

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Transcript NM_006218.4
gDNA chr3:g.179199066G>A
cDNA c.241G>A
Protein p.E81K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.5 chr3:g.179199066G>A c.241G>A p.E81K RefSeq GRCh38/hg38
XM_006713658 chr3:g.179199066G>A c.241G>A p.E81K RefSeq GRCh38/hg38
NM_006218 chr3:g.179199066G>A c.241G>A p.E81K RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179199066G>A c.241G>A p.E81K RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179199066G>A c.241G>A p.E81K RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179199066G>A c.241G>A p.E81K RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179199066G>A c.241G>A p.E81K RefSeq GRCh38/hg38
XM_011512894 chr3:g.179199066G>A c.241G>A p.E81K RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References