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Gene TP53
Variant I255N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 I255N lies within the DNA-binding domain of the Tp53 protein (PMID: 15510160). I255N has been identified in the scientific literature (PMID: 32945487), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 I255N

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Transcript NM_000546.6
gDNA chr17:g.7674199A>T
cDNA c.764T>A
Protein p.I255N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114.2 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674199A>T c.764T>A p.I255N RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 I255N acute myeloid leukemia predicted - sensitive thioureidobutyronitrile Preclinical - Patient cell culture Actionable In a preclinical study, Kevetrin (thioureidobutyronitrile) treatment resulted in apoptosis of leukemic blast cells and decreased cell viability in patient-derived acute myeloid leukemia cells harboring TP53 I255N in culture (PMID: 32945487). 32945487