PIK3CA G118D
Gene Variant Detail

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Gene PIK3CA
Variant G118D
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA G118D lies within the region linking the PI3K-ABD and PI3K-RBD domains of the Pik3ca protein (UniProt.org). G118D confers a gain of function on the Pik3ca protein as indicated by enhanced lipid kinase activity and binding in in vitro assays (PMID: 22949682), increased phosphorylation of Akt in cells derived from Cowden syndrome patients harboring germline mutations (PMID: 23246288), and increased transformation ability in two different cell lines (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA G118D

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Transcript NM_006218.4
gDNA chr3:g.179199690G>A
cDNA c.353G>A
Protein p.G118D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179199690G>A c.353G>A p.G118D RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179199690G>A c.353G>A p.G118D RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179199690G>A c.353G>A p.G118D RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179199690G>A c.353G>A p.G118D RefSeq GRCh38/hg38
NM_006218 chr3:g.179199690G>A c.353G>A p.G118D RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179199690G>A c.353G>A p.G118D RefSeq GRCh38/hg38
XM_006713658 chr3:g.179199690G>A c.353G>A p.G118D RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179199690G>A c.353G>A p.G118D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA G118D lung non-small cell carcinoma sensitive LY3023414 Preclinical - Cell line xenograft Actionable In a preclinical study, LY3023414 inhibited proliferation of non-small cell lung cancer cells harboring PIK3CA G118D in culture, resulted in tumor growth inhibition in cell line xenograft models (PMID: 27439478). 27439478
PIK3CA G118D head and neck squamous cell carcinoma sensitive Alpelisib + Tipifarnib Preclinical - Pdx Actionable In a preclinical study, the combination of Piqray (alpelisib) and Zarnestra (tipifarnib) inhibited tumor growth in a patient-derived xenograft (PDX) model of head and neck squamous cell carcinoma harboring PIK3CA G118D (PMID: 37339176). 37339176