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Gene PIK3CA
Variant G512*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions PIK3CA G512* results in a premature truncation of the Pik3ca protein at amino acid 512 of 1068 (UniProt.org). Due to the loss of the PI3K/PI4K kinase domain (UniProt.org), G512* is predicted to lead to a loss of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon9 PIK3CA G512*

PIK3CA mutant PIK3CA inact mut PIK3CA G512*

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Transcript NM_006218.4
gDNA chr3:g.179210560G>T
cDNA c.1534G>T
Protein p.G512*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218 chr3:g.179210560G>T c.1534G>T p.G512* RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210560G>T c.1534G>T p.G512* RefSeq GRCh38/hg38
XM_006713658 chr3:g.179210560G>T c.1534G>T p.G512* RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210560G>T c.1534G>T p.G512* RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210560G>T c.1534G>T p.G512* RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210560G>T c.1534G>T p.G512* RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210560G>T c.1534G>T p.G512* RefSeq GRCh38/hg38
XM_011512894 chr3:g.179210560G>T c.1534G>T p.G512* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
PIK3CA G512* loss of function - predicted