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Gene FGFR2
Variant A315C
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 A315C lies within Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). A315C has not been characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 A315C

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Transcript NM_000141.5
gDNA chr10:g.121517459_121517460delGCinsTG
cDNA c.943_944delGCinsTG
Protein p.A315C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121517459_121517460delGCinsTG c.943_944delGCinsTG p.A315C RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121517459_121517460delGCinsTG c.943_944delGCinsTG p.A315C RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121517459_121517460delGCinsTG c.943_944delGCinsTG p.A315C RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121517459_121517460delGCinsTG c.943_944delGCinsTG p.A315C RefSeq GRCh38/hg38
NM_001144918.2 chr10:g.121503934_121503935delGCinsTG c.943_944delGCinsTG p.A315C RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References