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Gene TP53
Variant N345Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 N345Y lies within the tetramerization domain of the Tp53 protein (PMID: 20978130). N345Y results in predominantly monomeric Tp53, but retains transactivation activity in yeast assays (PMID: 16007150), but has has not been characterized in human cells and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 N345Y

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Transcript NM_000546.6
gDNA chr17:g.7670676T>A
cDNA c.1033A>T
Protein p.N345Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.6 chr17:g.7670676T>A c.1033A>T p.N345Y RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670676T>A c.1033A>T p.N345Y RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670676T>A c.1033A>T p.N345Y RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670676T>A c.1033A>T p.N345Y RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670676T>A c.1033A>T p.N345Y RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670676T>A c.1033A>T p.N345Y RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670676T>A c.1033A>T p.N345Y RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References