Gene Variant Detail

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Gene TP53
Variant K357R
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 K357R lies within the HIPK1, CARM1, and HIPK2-interacting regions of the Tp53 protein (UniProt.org). K357R results in decreased Tp53-mediated transcription of p21 in cultured cells (PMID: 27210019), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 K357R

TP53 mutant TP53 inact mut TP53 K357R

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Transcript NM_000546.6
gDNA chr17:g.7670639T>C
cDNA c.1070A>G
Protein p.K357R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7670639T>C c.1070A>G p.K357R RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670639T>C c.1070A>G p.K357R RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670639T>C c.1070A>G p.K357R RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670639T>C c.1070A>G p.K357R RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670639T>C c.1070A>G p.K357R RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670639T>C c.1070A>G p.K357R RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670639T>C c.1070A>G p.K357R RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References