TP53 L348S
Gene Variant Detail

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Gene TP53
Variant L348S
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 L348S lies within the tetramerization domain of the Tp53 protein (PMID: 20978130). L348S results in decreased Tp53 tetramerization and thermal stability in in vitro assays (PMID: 20978130), and therefore, is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 L348S

TP53 mutant TP53 inact mut TP53 L348S

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Transcript NM_000546.6
gDNA chr17:g.7670666A>G
cDNA c.1043T>C
Protein p.L348S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.6 chr17:g.7670666A>G c.1043T>C p.L348S RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670666A>G c.1043T>C p.L348S RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670666A>G c.1043T>C p.L348S RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670666A>G c.1043T>C p.L348S RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670666A>G c.1043T>C p.L348S RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670666A>G c.1043T>C p.L348S RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670666A>G c.1043T>C p.L348S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries