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Gene TP53
Variant A347D
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 A347D lies within the tetramerization domain of the Tp53 protein (UniProt.org). A347D results in results in decreased Tp53 tetramerization and increased colony formation in cell culture (PMID: 29955864).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 A347D

TP53 mutant TP53 inact mut TP53 A347D

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Transcript NM_000546.6
gDNA chr17:g.7670669G>T
cDNA c.1040C>A
Protein p.A347D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.3 chr17:g.7670669G>T c.1040C>A p.A347D RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670669G>T c.1040C>A p.A347D RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670669G>T c.1040C>A p.A347D RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670669G>T c.1040C>A p.A347D RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670669G>T c.1040C>A p.A347D RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670669G>T c.1040C>A p.A347D RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670669G>T c.1040C>A p.A347D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
TP53 A347D loss of function p53 Activator p53 Gene Therapy