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Gene TP53
Variant L350P
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 L350P lies within the tetramerization domain of the Tp53 protein (PMID: 20978130). L350P results in decreased binding to Tfap2a, decreased Tp53 transactivation activity in a reporter assay, and decreased induction of p21 gene expression in cell culture (PMID: 16288208).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 L350P

TP53 mutant TP53 inact mut TP53 L350P

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Transcript NM_000546.6
gDNA chr17:g.7670660A>G
cDNA c.1049T>C
Protein p.L350P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112.3 chr17:g.7670660A>G c.1049T>C p.L350P RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670660A>G c.1049T>C p.L350P RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670660A>G c.1049T>C p.L350P RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670660A>G c.1049T>C p.L350P RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670660A>G c.1049T>C p.L350P RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670660A>G c.1049T>C p.L350P RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670660A>G c.1049T>C p.L350P RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References