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PIK3CA H701P - Gene Variant Detail

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Gene PIK3CA
Variant H701P
Impact List missense
Protein Effect no effect
Gene Variant Descriptions PIK3CA H701P does not lie within any known functional domains of the Pik3ca protein (UniProt.org). H701P demonstrates transformation potential and ability to promote growth factor-independent cell survival at similar levels to wild-type Pik3ca protein in cell culture (PMID: 26627007, PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA H701P

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Transcript NM_006218.4
gDNA chr3:g.179221072A>C
cDNA c.2102A>C
Protein p.H701P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218 chr3:g.179221072A>C c.2102A>C p.H701P RefSeq GRCh38/hg38
XM_006713658 chr3:g.179221072A>C c.2102A>C p.H701P RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179221072A>C c.2102A>C p.H701P RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179221072A>C c.2102A>C p.H701P RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179221072A>C c.2102A>C p.H701P RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179221072A>C c.2102A>C p.H701P RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179221072A>C c.2102A>C p.H701P RefSeq GRCh38/hg38
XM_011512894 chr3:g.179221072A>C c.2102A>C p.H701P RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References