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Gene PIK3CA
Variant K111N
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA K111N lies within the region linking the PI3K-ABD and PI3K-RBD domains of the Pik3ca protein (UniProt.org). K111N results in increased phosphorylation of Akt, activation of downstream signaling, increased cell proliferation and migration, and is transforming in cell culture (PMID: 17376864, PMID: 29533785, PMID: 34779417).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA K111N

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Transcript NM_006218.4
gDNA chr3:g.179199158G>C
cDNA c.333G>C
Protein p.K111N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658 chr3:g.179199158G>C c.333G>C p.K111N RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179199158G>C c.333G>C p.K111N RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179199158G>C c.333G>C p.K111N RefSeq GRCh38/hg38
NM_006218 chr3:g.179199158G>C c.333G>C p.K111N RefSeq GRCh38/hg38
XM_011512894 chr3:g.179199158G>C c.333G>C p.K111N RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179199158G>C c.333G>C p.K111N RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179199158G>C c.333G>C p.K111N RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179199158G>C c.333G>C p.K111N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
PIK3CA K111N gain of function Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor