PTEN E73K
Gene Variant Detail

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Gene PTEN
Variant E73K
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN E73K lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). E73K leads to normal developmental growth in flies, but demonstrates reduced Pten protein stability and results in partial suppression of Akt phosphorylation in cell culture (PMID: 32350270), and therefore is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN E73K

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Transcript NM_000314.8
gDNA chr10:g.87931053G>A
cDNA c.217G>A
Protein p.E73K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.8 chr10:g.87931053G>A c.217G>A p.E73K RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87931053G>A c.217G>A p.E73K RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References