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Gene STK11
Variant L45fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 L45fs results in a change in the amino acid sequence of the Stk11 protein beginning at aa 45 of 433, likely resulting in premature truncation of the functional protein (UniProt.org). L45fs has not been characterized however, due to the effects of other truncation mutations downstream of L45 (PMID: 23612973), is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 L45fs

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Transcript NM_000455.5
gDNA chr19:g.(1207045_1207046)
cDNA c.(133_132)
Protein p.L45fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.4 chr19:g.(1207045_1207046) c.(133_132) p.L45fs RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.(1207045_1207046) c.(133_132) p.L45fs RefSeq GRCh38/hg38
NM_000455.5 chr19:g.(1207045_1207046) c.(133_132) p.L45fs RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.(1207045_1207046) c.(133_132) p.L45fs RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.(1207045_1207046) c.(133_132) p.L45fs RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References