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Gene PIK3CA
Variant N457K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA N457K lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). N457K has been identified in the scientific literature (PMID: 29636477, PMID: 19844788), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Nov 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA N457K

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Transcript NM_006218.4
gDNA chr3:g.179210305C>G
cDNA c.1371C>G
Protein p.N457K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.5 chr3:g.179210305C>G c.1371C>G p.N457K RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210305C>G c.1371C>G p.N457K RefSeq GRCh38/hg38
NM_006218 chr3:g.179210305C>G c.1371C>G p.N457K RefSeq GRCh38/hg38
XM_011512894 chr3:g.179210305C>G c.1371C>G p.N457K RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210305C>G c.1371C>G p.N457K RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210305C>G c.1371C>G p.N457K RefSeq GRCh38/hg38
XM_006713658 chr3:g.179210305C>G c.1371C>G p.N457K RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210305C>G c.1371C>G p.N457K RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References