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Gene PIK3CA
Variant R115L
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA R115L does not lie within any known functional domains of the Pik3ca protein (UniProt.org). R115L confers a gain of function to the Pik3ca protein as demonstrated by increased cell growth, activation of the PI3K pathway (PMID: 23619167), and increased transformation ability in two different cell lines, as compared to wild-type Pik3ca (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA R115L

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Transcript NM_006218.4
gDNA chr3:g.179199169G>T
cDNA c.344G>T
Protein p.R115L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894.2 chr3:g.179199169G>T c.344G>T p.R115L RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179199169G>T c.344G>T p.R115L RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179199169G>T c.344G>T p.R115L RefSeq GRCh38/hg38
NM_006218 chr3:g.179199169G>T c.344G>T p.R115L RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179199169G>T c.344G>T p.R115L RefSeq GRCh38/hg38
XM_006713658 chr3:g.179199169G>T c.344G>T p.R115L RefSeq GRCh38/hg38
XM_011512894 chr3:g.179199169G>T c.344G>T p.R115L RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179199169G>T c.344G>T p.R115L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References